镰状细胞病中的人类红细胞膜腺苷酸环化酶
Human red blood cell membrane adenylate cyclase in sickle-cell disease.
作者信息
Delaunay J, Piau J P, Girot R, Fischer S, Tortolero M, Schapira G
出版信息
Isr J Med Sci. 1978 Nov;14(11):1170-2.
PMID:750545
Abstract
The basal and the NaF-stimulated activities of human red blood cell membrane adenylate cyclase were found to be 5.3 +/- 0.8 (SE) and 219 +/- 76 (SE) pmol . mg-1 . min-1, respectively. Both activities were increased in nine patients with homozygous sickle-cell disease. There was no apparent correlation between this increase and the increase in the reticulocyte count.
摘要
发现人类红细胞膜腺苷酸环化酶的基础活性和氟化钠刺激后的活性分别为5.3±0.8（标准误）和219±76（标准误）pmol·mg⁻¹·min⁻¹。在9例纯合子镰状细胞病患者中，这两种活性均升高。这种升高与网织红细胞计数的增加之间没有明显的相关性。
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