Sidorova L D, Bondar' I A, Iavorskaia V E, Evstropov A N
Ter Arkh. 1993;65(10):20-3.
The investigation of interferon status in 54 diabetes mellitus patients gave evidence for high levels of blood serum interferon, leukocyte inhibition of alpha-interferon production against moderate synthesis of gamma interferon. More marked alterations in the interferon status were registered in severe insulin-dependent diabetes mellitus complicated by angiopathies and running more than 5 years. Compensation of metabolic processes was not relevant to interferon status. Variations in the levels of alpha- and gamma-interferons in the course ob observation occurred in 30% of the patients.
对54例糖尿病患者的干扰素状态进行调查发现，血清干扰素水平较高，白细胞对α干扰素产生的抑制作用与γ干扰素的适度合成有关。在伴有血管病变且病程超过5年的重度胰岛素依赖型糖尿病患者中，干扰素状态的改变更为明显。代谢过程的代偿与干扰素状态无关。在观察过程中，30%的患者出现了α和γ干扰素水平的变化。
