血管活性肠肽（VIP）与新型肽垂体腺苷酸环化酶激活肽（PACAP）对大鼠胰腺外分泌作用的比较。

Comparison between the effects of VIP and the novel peptide PACAP on the exocrine pancreatic secretion of the rat.

作者信息

Alonso R M, Rodríguez A M, García L J, López M A, Calvo J J

机构信息

Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain.

出版信息

Pancreas. 1994 Jan;9(1):123-8. doi: 10.1097/00006676-199401000-00018.

DOI:10.1097/00006676-199401000-00018

PMID:7509062

Abstract

The effect of intravenous infusion of pituitary adenylate cyclase-activating peptide (PACAP) 27, a novel regulatory peptide that shows a close structural and chemical similarity to vasoactive intestinal peptide (VIP), on the rat exocrine pancreatic secretion was studied. PACAP and VIP stimulated the flow rate of exocrine pancreatic secretion (p < 0.05). However, protein output and amylase secretion were mainly stimulated by PACAP. Intravenous infusion of VIP increased the plasma levels of secretin (p < 0.05). On the other hand, PACAP released neither secretin nor VIP. Our results show: (a) both PACAP and VIP stimulate exocrine pancreatic secretion, (b) PACAP stimulation of pancreatic amylase and protein secretion is greater than that induced by VIP, and (c) PACAP probably exerts a direct effect on exocrine pancreas whereas some of the actions of VIP might be mediated by secretin.

摘要

研究了静脉输注垂体腺苷酸环化酶激活肽（PACAP）27对大鼠胰腺外分泌的影响。PACAP 27是一种新型调节肽，其结构和化学性质与血管活性肠肽（VIP）极为相似。PACAP和VIP均刺激了胰腺外分泌的流速（p<0.05）。然而，蛋白质输出和淀粉酶分泌主要受PACAP刺激。静脉输注VIP可使促胰液素的血浆水平升高（p<0.05）。另一方面，PACAP既不释放促胰液素也不释放VIP。我们的结果表明：（a）PACAP和VIP均刺激胰腺外分泌；（b）PACAP对胰腺淀粉酶和蛋白质分泌的刺激作用大于VIP；（c）PACAP可能对胰腺外分泌发挥直接作用，而VIP的某些作用可能由促胰液素介导。