Rodríguez-López A M, De Dios I, García L J, López M A, Calvo J J
Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain.
Rev Esp Fisiol. 1995 Mar;51(1):29-36.
A dose-response study of the effects of vasoactive intestinal peptide (VIP) on the exocrine pancreatic secretion of the rabbit has been made. Furthermore, the actions of VIP and pituitary adenylate cyclase activating peptide (PACAP) on the exocrine pancreatic secretion were compared at a similar molar dose. After the infusion of VIP a linear dose-response relationship for pancreatic flow rate and bicarbonate output, up to the dose of 4 micrograms/kg, was observed. VIP acts as a partial agonist of secretin, the rabbit pancreas being less sensitive to VIP compared with other mammals. Moreover, VIP did not significantly stimulate the pancreatic protein output. PACAP stimulated the hydroelectrolyte fraction of the exocrine pancreatic secretion in a similar manner to that of VIP. Unlike what was observed with VIP, PACAP, on the same molar basis, significantly stimulated the protein and amylase outputs. Furthermore, PACAP releases VIP, so that the action of PACAP on the hydroelectrolyte fraction may be partially mediated by VIP; on the other hand, VIP is not involved in the effect of PACAP on the pancreatic enzyme secretion of this species.
已对血管活性肠肽（VIP）对兔胰腺外分泌的影响进行了剂量反应研究。此外，还在相似摩尔剂量下比较了VIP和垂体腺苷酸环化酶激活肽（PACAP）对胰腺外分泌的作用。输注VIP后，观察到胰腺流速和碳酸氢盐输出呈线性剂量反应关系，直至剂量达到4微克/千克。VIP作为促胰液素的部分激动剂，与其他哺乳动物相比，兔胰腺对VIP的敏感性较低。此外，VIP并未显著刺激胰腺蛋白质输出。PACAP以与VIP相似的方式刺激胰腺外分泌的水电解质部分。与VIP不同的是，在相同摩尔基础上，PACAP显著刺激蛋白质和淀粉酶输出。此外，PACAP释放VIP，因此PACAP对水电解质部分的作用可能部分由VIP介导；另一方面，VIP不参与PACAP对该物种胰腺酶分泌的影响。
