苯乙双胍和芬氟拉明长期过量服用后导致的急性肌肉坏死。
Acute muscle necrosis after chronic overdosage of phenformin and fenfluramine.
作者信息
Palmucci L, Bertolotto A, Schiffer D
出版信息
Muscle Nerve. 1978 May-Jun;1(3):245-7. doi: 10.1002/mus.880010311.
PMID:750925
Abstract
A case of acute muscle necrosis with probable myoglobinuria is presented. The patient had been taking excessive doses of phenformin and fenfluramine, and a toxic etiology is suggested. Muscle necrosis is tentatively attributed either to the combined effect of these drugs on some underlying biochemical abnormality of muscle or to a defect of oxygen utilization secondary to myoglobin alterations.
摘要
本文报告一例可能伴有肌红蛋白尿的急性肌肉坏死病例。该患者曾过量服用苯乙双胍和芬氟拉明，提示存在中毒病因。肌肉坏死初步归因于这些药物对肌肉某些潜在生化异常的联合作用，或继发于肌红蛋白改变的氧利用缺陷。
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