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急性林丹中毒伴肌肉坏死形成

Acute lindane poisoning with development of muscle necrosis.

作者信息

Munk Z M, Nantel A

出版信息

Can Med Assoc J. 1977 Nov 5;117(9):1050-4.

PMID:71942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1880185/
Abstract

A 35-year-old man ingested food contaminated with lindane, an insecticide containing almost pure gamma hexachlorocyclohexane. Grand mal seizures and severe acidemia developed rapidly. The seizures recurred for nearly 2 hours, then ceased. In addition, the patient had muscle weakness and pain, headaches, episodic hypertension, myoglobinuria, acute renal failure and anemia. Pancreatitis developed 13 days after the ingestion of lindane. A muscle biopsy on the 15th day of illness demonstrated widespread necrosis and regeneration of muscle fibres. The patient's condition improved and he was discharged 24 days after the onset of his illness. During the year following the poisoning the patient noted difficulty with recent memory, loss of libido and easy fatigability. One year after lindane ingestion the results of physical examination, including those for muscle power and bulk, were normal.

摘要

一名35岁男子摄入了被林丹污染的食物,林丹是一种几乎含有纯γ-六氯环己烷的杀虫剂。很快就出现了癫痫大发作和严重酸血症。癫痫发作反复持续了近2小时,随后停止。此外,患者还出现肌肉无力和疼痛、头痛、发作性高血压、肌红蛋白尿、急性肾衰竭和贫血。摄入林丹13天后发生了胰腺炎。发病第15天的肌肉活检显示肌纤维广泛坏死和再生。患者病情好转,发病24天后出院。在中毒后的一年里,患者注意到近期记忆力减退、性欲丧失和易疲劳。摄入林丹一年后,体格检查结果,包括肌肉力量和体积检查,均正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ea/1880185/0459e332e9e0/canmedaj01515-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ea/1880185/0459e332e9e0/canmedaj01515-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62ea/1880185/0459e332e9e0/canmedaj01515-0073-a.jpg

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