Lewis E G, Dustman R E, Beck E C
Electroencephalogr Clin Neurophysiol. 1978 Feb;44(2):223-31. doi: 10.1016/0013-4694(78)90268-7.
The effects of prolonged hemodialysis and kidney transplantation on visual and somatosensory evoked potentials and EEG frequency were assessed. Significant changes were found in both amplitude and latency characteristics of evoked potentials recorded from eight hemodialysis patients. Their evoked potentials tended to be of longer latency and larger amplitude when compared to responses of an age-matched control group. This was true for visual and somatosensory responses recorded from several scalp locations. A correlational analysis revealed no consistent relationship between blood chemistries and evoked potential characteristics. EEG power spectral analysis showed that the dominant frequency of five of the eight dialysis patients was in the 8-10 c/sec range. Two other patients demonstrated EEG frequencies which were scattered across the 3-12 c/sec range while for another subject the dominant frequency was 7-8 c/sec. The evoked potential latencies and amplitudes of patients with successful kidney transplant tended to return to the normal range and their predominant EEG frequency increased to around 10 c/sec. A depression of function in those neural systems underlying the visual and somatosensory modalities, along with a reduction in the cortical suppression of afferent stimulation normally exerted by the thalamic reticular system and the basal ganglia were postulated to account for the reported findings.
评估了长期血液透析和肾移植对视觉和体感诱发电位以及脑电图频率的影响。在8名血液透析患者记录的诱发电位的波幅和潜伏期特征方面均发现了显著变化。与年龄匹配的对照组的反应相比，他们的诱发电位潜伏期往往更长，波幅更大。从几个头皮部位记录的视觉和体感反应均是如此。相关性分析显示血液化学成分与诱发电位特征之间没有一致的关系。脑电图功率谱分析表明，8名透析患者中有5人的主导频率在8 - 10赫兹范围内。另外两名患者的脑电图频率分布在3 - 12赫兹范围内，而另一名受试者的主导频率为7 - 8赫兹。肾移植成功的患者的诱发电位潜伏期和波幅往往恢复到正常范围，其脑电图的主导频率增加到约10赫兹。据推测，视觉和体感模式下的那些神经系统功能减退，以及丘脑网状系统和基底神经节通常对传入刺激的皮质抑制作用减弱，是导致上述报告结果的原因。
