Lewis E G, O'Neill W M, Dustman R E, Beck E C
Kidney Int. 1980 Mar;17(3):357-63. doi: 10.1038/ki.1980.41.
The short-term effects of hemodialysis on the integrity of the central nervous system (CNS) were examined. Evoked potentials (EP) and performance on five neuropsychologic tests were obtained from six patients undergoing maintenance hemodialysis. Measurements were taken 1, 24, 42, and 66b hours following dialysis. A highly consistent relationship between time since dialysis and EP latency was found. EP latencies tended to decrease during the 1-hour and the 24-hour recording sessions (compared to predialysis recordings), the shortest latencies typically occurring during the 24-hour period, then increasing steadily during the 42-hour and 66-hour intervals. EP amplitude was largest 1 hour after dialysis, then decreased progressively with time since dialysis. Performance on two tests of visual-motor speed and accuracy was best 24 hours after dialysis. The results indicate that there are consistent and measurable changes in the responsivity of the CNS which are related to time since dialysis.
研究了血液透析对中枢神经系统（CNS）完整性的短期影响。对6名接受维持性血液透析的患者进行了诱发电位（EP）检查，并让他们接受了五项神经心理学测试。在透析后1、24、42和66小时进行测量。发现透析后时间与EP潜伏期之间存在高度一致的关系。在1小时和24小时的记录期间（与透析前记录相比），EP潜伏期往往会缩短，最短潜伏期通常出现在24小时期间，然后在42小时和66小时期间稳步增加。透析后1小时EP波幅最大，然后随透析后时间逐渐降低。视觉运动速度和准确性的两项测试成绩在透析后24小时最佳。结果表明，中枢神经系统的反应性存在与透析后时间相关的一致且可测量的变化。
