Tarnawski A, Goszcz A, Bogdał J, Barylak H, Mach T
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):621-6.
After 3 hr of perfusion of isolated guinea pig liver with a medium containing 407 ng/ml of phenazone, the drug concentration in the bile was 1.5 times higher than the initial concentration in the perfusion fluid. This indicates that in addition to phenazone metabolism, liver eliminates the drug by active releasing it to the bile. The active release is responsible for depression of phenazone concentration during the perfusion in approx. 6%. The remaining loss of phenazone is due to its hepatic metabolism.
用含有407纳克/毫升非那宗的培养基对离体豚鼠肝脏进行3小时灌注后，胆汁中的药物浓度比灌注液中的初始浓度高1.5倍。这表明，除了非那宗代谢外，肝脏还通过将药物主动释放到胆汁中来消除药物。主动释放导致灌注过程中非那宗浓度降低约6%。非那宗其余的损失是由于其肝脏代谢。
