Mach T, Goszcz A, Bogdał J, Barylak H, Tarnawski A
Acta Physiol Pol. 1978 May-Jun;29(3):267-72.
The aim of these investigations was to elucidate in which part of the bile system (canaliculi or ductules) antipyrine is secreted actively into bile during extracorporeal perfusion of isolated guinea pig liver. Twelve perfusions were performed including 6 control and 6 with secretin. After 1, 2 and 3 hours from the onset of perfusion the perfusion fluid and bile samples were taken for determination of antipyrine concentration. It was demonstrated that secretin increases the volume of secreted bile, the concentration of antipyrine was decreased and the total amount of antipyrine eliminated with bile remained unchanged. The obtained results refute the hypothesis that antipyrine is secreted into bile in the ductular phase and suggest that this process takes place at the level of biliary canaliculi.
这些研究的目的是阐明在离体豚鼠肝脏体外灌注过程中，安替比林在胆汁系统的哪个部分（胆小管或小胆管）被主动分泌到胆汁中。进行了12次灌注，其中6次为对照，6次使用促胰液素。在灌注开始后的1、2和3小时，采集灌注液和胆汁样本以测定安替比林浓度。结果表明，促胰液素增加了胆汁分泌量，安替比林浓度降低，而随胆汁排出的安替比林总量保持不变。所得结果反驳了安替比林在小胆管期分泌到胆汁中的假说，并表明这一过程发生在胆小管水平。
