Rha K S, Majima Y, Sakakura Y, Yasui Y, Nakano K, Ishihara A
Dept of Otorhinolaryngology, Mie University School of Medicine, Japan.
Ann Otol Rhinol Laryngol. 1994 Mar;103(3):222-6. doi: 10.1177/000348949410300310.
Immunohistochemistry combined with electron microscopy was employed to investigate the distribution of substance P-immunoreactive (SP-IR) nerve fibers in the tracheal submucosal gland of cats. The SP-IR nerve fibers were found to form a network around the glands. Numerous varicosities were also detected within the basement membrane of the acini and secretory tubules. All the intraglandular varicosities showed close spatial contact with serous cells, mucous cells, and myoepithelial cells. Our findings suggest that substance P-induced mucus secretion from tracheal submucosal glands in cats may be caused not only by a glandular contractile response of myoepithelial cells, but also by direct stimulation to both serous and mucous cells.
采用免疫组织化学结合电子显微镜技术，研究猫气管黏膜下腺中P物质免疫反应性（SP-IR）神经纤维的分布。发现SP-IR神经纤维在腺体周围形成网络。在腺泡和分泌小管的基底膜内也检测到许多曲张体。所有腺内曲张体均与浆液性细胞、黏液性细胞和肌上皮细胞有紧密的空间接触。我们的研究结果表明，P物质诱导猫气管黏膜下腺分泌黏液，可能不仅是由肌上皮细胞的腺体收缩反应引起的，还可能是由对浆液性细胞和黏液性细胞的直接刺激引起的。
