Mills J W, Quinton P M
Am J Physiol. 1981 Jul;241(1):C18-24. doi: 10.1152/ajpcell.1981.241.1.C18.
Parenchymal cells of exocrine glands have been reported to develop numerous large vacuoles when intensely stimulated either pharmacologically, electrically, or physiologically. We have found that tracheal submucosal glands of the cat form similar vacuoles in response to alpha-adrenergic stimulation. Light and electron microscope examination of tracheal submucosal glands stimulated in vitro with methoxamine (10(-4) M) reveals that only serous cells of the gland acini develop vacuoles. Ductal cells and mucous acinar cells do not form vacuoles. Furthermore, several lines of evidence indicate that within serous cells vacuoles arise from secretory granules, which apparently swell as they accumulate fluid during intense stimulation. The following paper describes some of the factors and characteristics of stimulus-induced vacuolation.
据报道，外分泌腺的实质细胞在受到药理学、电生理学或生理学的强烈刺激时，会形成大量大液泡。我们发现，猫的气管黏膜下腺在α-肾上腺素能刺激下会形成类似的液泡。用甲氧明（10^(-4) M）体外刺激气管黏膜下腺后，进行光镜和电镜检查发现，只有腺泡的浆液性细胞会形成液泡。导管细胞和黏液性腺泡细胞不会形成液泡。此外，有几条证据表明，在浆液性细胞内，液泡起源于分泌颗粒，在强烈刺激过程中，当它们积累液体时，这些颗粒显然会膨胀。以下论文描述了刺激诱导空泡化的一些因素和特征。
