Carpino A, Sisci D, Aquila S, Salerno M, Siciliano L, Sessa M, Andò S
Department of Cellular Biology, University of Calabria, Cosenza, Italy.
Arch Androl. 1994 Jan-Feb;32(1):37-43. doi: 10.3109/01485019408987765.
Prostatic acid phosphatase, prostate-specific antigen, and zinc as markers of prostate, and fructose as marker of seminal vesicles were investigated in the seminal plasma of 35 idiopathic asthenozoospermic and 20 normal subjects to evaluate their relationship with sperm motility. Total seminal plasma levels of the three prostatic markers and, to a lesser extent, total fructose levels were lower in asthenozoospermic patients, and in all the pooled subjects, the same levels were directly correlated with the motility of ejaculated spermatozoa. When the levels of the biochemical markers were expressed as concentrations in seminal plasma, only prostatic acid phosphatase levels remained lower in asthenozoospermic patients and they maintained a direct correlation with sperm motility in all the pooled subjects. The PAP/Zn/Fr (representing the ratio between PAP concentration and free Zn available for spermatozoan uptake) was lower in asthenozoospermic patients and it was also directly related to sperm motility in all the pooled subjects. These data suggest that altered sperm motility is associated with a probable impairment of sex accessory gland function in subjects with idiopathic asthenozoospermia, while prostatic acid phosphatase seems mainly related to sperm motility.
对35例特发性弱精子症患者和20例正常受试者的精浆进行了研究，检测了前列腺酸性磷酸酶、前列腺特异性抗原和锌作为前列腺的标志物，以及果糖作为精囊的标志物，以评估它们与精子活力的关系。弱精子症患者的三种前列腺标志物的精浆总水平以及果糖总水平在一定程度上较低，在所有汇总受试者中，这些水平与射出精子的活力直接相关。当生化标志物的水平以精浆中的浓度表示时，只有前列腺酸性磷酸酶水平在弱精子症患者中仍然较低，并且在所有汇总受试者中它们与精子活力保持直接相关性。弱精子症患者的PAP/Zn/Fr（代表PAP浓度与精子可摄取的游离锌之间的比率）较低，并且在所有汇总受试者中它也与精子活力直接相关。这些数据表明，在特发性弱精子症患者中，精子活力改变可能与性腺附属性腺功能受损有关，而前列腺酸性磷酸酶似乎主要与精子活力相关。
