1-芳基-2-氨基/肼基-4-苯基-1,6-二氢-1,3,5-三嗪-6-硫酮及相关硫代碳酰胺/硫代氨基脲作为抗甲状腺药物。
1-Aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thione and related thiocarbamides/thiosemicarbazides as antithyroidal agents.
作者信息
Prasad R, Srivastava P K
机构信息
Department of Chemistry, Banaras Hindu University, Varanasi, India.
出版信息
Arch Pharm (Weinheim). 1993 Dec;326(12):963-6. doi: 10.1002/ardp.19933261210.
Different 1-aryl-2-benzylmercapto-4-phenyl-1,6-dihydro-1,3,5-triazine-6- thiones have been synthesized by known methods. These triazines on treatment with ammonia/hydrazine hydrate afforded the corresponding 1-aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thiones which on treatment with arylisothiocyanates afforded the related thiocarbamide/thiosemicarbazides. Some of these compounds show appreciable antithyroidal activity.
已通过已知方法合成了不同的1-芳基-2-苄基巯基-4-苯基-1,6-二氢-1,3,5-三嗪-6-硫酮。这些三嗪与氨/水合肼反应得到相应的1-芳基-2-氨基/肼基-4-苯基-1,6-二氢-1,3,5-三嗪-6-硫酮，后者与异硫氰酸芳酯反应得到相关的硫脲/氨基硫脲。其中一些化合物显示出明显的抗甲状腺活性。
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