Groszkowski S, Wrona J
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):713-5.
By the condensation of 1,2-di(chloracetyl)piperidazine with primary amines 3-substituted derivatives of 1,5-diketoperhydropyridazino[1,2-a] 1,2,5-triazepine (1--8, Fig. 1) were obtained. Some of them show sedative action at the 25--100 mg/k dosis level and are of low ip toxicity.
通过1,2 - 二（氯乙酰基）哌嗪与伯胺缩合，得到了1,5 - 二酮哌啶并[1,2 - a]1,2,5 - 三氮杂卓的3 - 取代衍生物（图1中的1 - 8）。其中一些在25 - 100mg/kg剂量水平显示出镇静作用，并且腹腔注射毒性较低。
