哒嗪并[1,2 - a]1,2,5 - 三氮杂卓类化合物。
Pyridazino[1,2-a] 1,2,5-triazepines.
作者信息
Groszkowski S, Wrona J
出版信息
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):713-5.
PMID:751011
Abstract
By the condensation of 1,2-di(chloracetyl)piperidazine with primary amines 3-substituted derivatives of 1,5-diketoperhydropyridazino[1,2-a] 1,2,5-triazepine (1--8, Fig. 1) were obtained. Some of them show sedative action at the 25--100 mg/k dosis level and are of low ip toxicity.
摘要
通过1,2 - 二（氯乙酰基）哌嗪与伯胺缩合，得到了1,5 - 二酮哌啶并[1,2 - a]1,2,5 - 三氮杂卓的3 - 取代衍生物（图1中的1 - 8）。其中一些在25 - 100mg/kg剂量水平显示出镇静作用，并且腹腔注射毒性较低。
相似文献
1
Pyridazino[1,2-a] 1,2,5-triazepines.哒嗪并[1,2 - a]1,2,5 - 三氮杂卓类化合物。
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):713-5.
2
3
[Preliminary studies on the central effects of new derivatives of pyridazino-[1,2a]-1,2,5-triazepine].
Acta Pol Pharm. 1979;36(4):497-502.
4
5
Pyridazines. XXXVIII. Pyridazino[4,5-e]-1,4-diazepine--a novel ring system of potential pharmaceutical interest.
Arch Pharm (Weinheim). 1988 May;321(5):309-10. doi: 10.1002/ardp.19883210515.
6
Synthesis and properties of N-methyl and N-phenyl derivatives of 1,4-dioxo-1,2,3,4-tetrahydropyrido[3,4-d]pyridazines.
Boll Chim Farm. 2004 Jun;143(5):211-8.
7
8
Chemical and pharmacological investigations on 2H-pyridazino[4,5-b] [1,4]benzothiazin-1(10H)-one derivatives.
Farmaco. 1989 Oct;44(10):911-32.
9
10
[On analgetically, antipyretically and antiphlogistically active sulphur-containing pyridazines (author's transl)].
Pharmazie. 1982 Feb;37(2):136-41.
引用本文的文献
1
Access to Nitrogen-nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases.通过哌嗪酸合酶的底物通用性获得含氮氮键的杂环化合物。
ACS Catal. 2025 May 12;15(11):8846-8854. doi: 10.1021/acscatal.5c01237. eCollection 2025 Jun 6.
Zotero 插件