de Vries J E, Punnonen J, Cocks B G, Aversa G
Human Immunology Department, DNAX Research Institute, Palo Alto, CA 94304-1104.
Semin Immunol. 1993 Dec;5(6):431-9. doi: 10.1006/smim.1993.1049.
Induction of immunoglobulin (Ig) isotype switching and isotype production by human B cells requires contact-mediated signals delivered by T helper cells in combination with cytokines. Effective T cell help requires T cell activation resulting in a rapid expression of T cell membrane proteins, which interact with ligands constitutively expressed on B cells. These interactions lead to B cell activation, proliferation and, in the presence of cytokines, to isotype switching and immunoglobulin synthesis. The nature of the T cell antigens involved in these T/B cell interactions, and their role in human B cell activation resulting in IgE synthesis in the presence of IL-4 and IL-13, will be discussed.
人B细胞免疫球蛋白（Ig）同种型转换及同种型产生的诱导需要辅助性T细胞传递的接触介导信号与细胞因子相结合。有效的T细胞辅助需要T细胞活化，从而导致T细胞膜蛋白快速表达，这些蛋白与B细胞组成性表达的配体相互作用。这些相互作用导致B细胞活化、增殖，并且在细胞因子存在的情况下，导致同种型转换和免疫球蛋白合成。将讨论参与这些T/B细胞相互作用的T细胞抗原的性质，以及它们在人B细胞活化中在IL-4和IL-13存在下导致IgE合成的作用。
