Kehry M R, Hodgkin P D
Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT 06877.
Semin Immunol. 1993 Dec;5(6):393-400. doi: 10.1006/smim.1993.1045.
In the effector phase of delivering T cell help for B cell differentiation, proteins induced following helper T cell activation deliver cell contact signals to the B cell that drive its activation and proliferation. Activation induced soluble lymphokines also deliver signals that, in conjunction with the contact signals, drive B cell differentiation and immunoglobulin class switching. Helper T cell activation leads to transient expression of a ligand for the constitutively expressed B cell surface protein, CD40. The CD40 ligand is involved in delivering the T cell induced contact signals. Regulation of synthesis of the CD40 ligand by activated helper T cells contributes to the maintenance of specificity of the antibody response. Knowledge of the molecules involved in delivering T cell help allows a clearer understanding of events regulating antibody affinity maturation, selection and class switching in vivo.
在为B细胞分化提供T细胞辅助的效应阶段，辅助性T细胞激活后诱导产生的蛋白质向B细胞传递细胞接触信号，驱动其激活和增殖。激活诱导的可溶性淋巴因子也传递信号，这些信号与接触信号一起，驱动B细胞分化和免疫球蛋白类别转换。辅助性T细胞激活导致组成性表达的B细胞表面蛋白CD40的配体短暂表达。CD40配体参与传递T细胞诱导的接触信号。活化的辅助性T细胞对CD40配体合成的调节有助于维持抗体反应的特异性。了解参与提供T细胞辅助的分子，有助于更清楚地理解体内调节抗体亲和力成熟、选择和类别转换的事件。
