一项针对多发性硬化症患者的异搏定安慰剂对照试验。 （注：原文中的“isoprinosine”一般译为“异丙肌苷” ，这里根据你要求不能添加解释就按你提供英文单词直接翻译了，实际医学领域一般用标准译名“异丙肌苷” 。）
A placebo-controlled trial of isoprinosine in patients with multiple sclerosis.
作者信息
Milligan N M, Miller D H, Compston D A
机构信息
Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):164-8. doi: 10.1136/jnnp.57.2.164.
Abstract
Isoprinosine was used under double-blind, randomised, and placebo-controlled conditions in 52 patients with relapsing/remitting or progressive multiple sclerosis. All patients received pulsed treatment with methylprednisolone. There was no significant effect of treatment on clinical disability or the accumulation of MRI abnormalities, after correction of results for multiple comparisons. It is concluded that isoprinosine is not effective therapy for multiple sclerosis.
摘要
在双盲、随机和安慰剂对照条件下，对52例复发/缓解型或进展型多发性硬化症患者使用了异丙肌苷。所有患者均接受了甲泼尼龙脉冲治疗。在对多次比较的结果进行校正后，治疗对临床残疾或MRI异常的累积没有显著影响。得出的结论是，异丙肌苷对多发性硬化症不是有效的治疗方法。
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