Freedman L J, Cassell M D
Neuroscience Program, University of Iowa, Iowa City 52242.
Brain Res. 1994 Jan 7;633(1-2):243-52. doi: 10.1016/0006-8993(94)91545-8.
The distribution of dopaminergic fibers in the principal components of the central extended amygdala (central amygdaloid nucleus (Ce), substantia innominata, and bed nucleus of the stria terminalis (BNST)), was studied using immunocytochemistry against tyrosine hydroxylase, dopamine beta-hydroxylase and dopamine. Dopamine fibers were found most densely distributed in the dorsolateral subdivision of the BNST and the lateral part of the Ce. Smaller numbers of dopaminergic fibers were found in the rest of the central extended amygdala. In contrast, dopamine beta-hydroxylase fibers were virtually absent from the dorsolateral bed nucleus of the stria terminalis and lateral part of the central amygdaloid nucleus, but were distributed in a moderate density in the medial part of Ce, dorsal substantia innominata and posterolateral BNST. Our results show that dopamine fibers are most concentration over those regions of the central extended amygdala with large numbers of GABAergic neurons whose projections remain within the central extended amygdala, while noradrenergic fibers are most heavily concentrated over those regions containing a large proportion of brainstem projection neurons. That dopamine fibers are concentrated over regions with GABAergic medium spiny neurons suggests that those regions might be organized as a striatal parallel.
利用抗酪氨酸羟化酶、多巴胺β-羟化酶和多巴胺的免疫细胞化学方法，研究了多巴胺能纤维在中央杏仁核扩展区主要成分（中央杏仁核（Ce）、无名质和终纹床核（BNST））中的分布。发现多巴胺纤维最密集地分布在终纹床核的背外侧亚区和中央杏仁核的外侧部分。在中央杏仁核扩展区的其他部位发现的多巴胺能纤维数量较少。相比之下，多巴胺β-羟化酶纤维在终纹床核背外侧和中央杏仁核外侧部分几乎不存在，但在中央杏仁核内侧部分、无名质背侧和终纹床核后外侧以中等密度分布。我们的结果表明，多巴胺纤维在中央杏仁核扩展区那些有大量γ-氨基丁酸能神经元且其投射仍在中央杏仁核扩展区内的区域最为集中，而去甲肾上腺素能纤维在含有大量脑干投射神经元的区域最为密集。多巴胺纤维集中在具有γ-氨基丁酸能中型多棘神经元的区域，这表明这些区域可能被组织成纹状体平行结构。
