Freedman L J, Shi C
Department of Neurology, Yerkes Primate Center, 954 Gatewood Rd., Atlanta, GA 30322, USA.
Neuroscience. 2001;104(4):1067-84. doi: 10.1016/s0306-4522(01)00157-9.
The extended amygdala is a group of structures including the central and medial amygdaloid nuclei, bed nucleus of the stria terminalis, and sublenticular substantia innominata. This group of structures is thought to be important in a variety of psychiatric disorders, many of which are linked in one way or another to monoamines and their transporters. However, not much is known about the distribution of these molecules in the primate extended amygdala. Thus, we mapped the distribution of fibers immunoreactive for tyrosine hydroxylase, dopamine beta-hydroxylase, serotonin, dopamine transporter, and serotonin transporter in the brains of macaque monkeys. Tyrosine hydroxylase-, serotonin-, and serotonin transporter-immunoreactive fibers were found in highest concentrations in the lateral division of the central nucleus and lateral dorsal part of the bed nucleus of the stria terminalis. Dopamine beta-hydroxylase-immunoreactive fibers were found in the highest concentration in the lateral ventral bed nucleus of the stria terminalis. Dopamine transporter-immunoreactive fibers were found in the highest concentrations in the lateral juxtacapsular and lateral dorsal capsular subnuclei of the bed nucleus and lateral capsular subnucleus of the central amygdaloid nucleus, though in much lower amounts than was present in the striatum. These results suggest prominent roles for these transmitters, particularly in the lateral dorsal bed nucleus and lateral part of the central nucleus. The relative absence of dopamine transporter in the extended amygdala suggests that this transmitter acts more through volume transmission while serotonin, which is generally accompanied by proportionate amounts of transporter, may act more like a classical neurotransmitter. In addition, the finding of heavy concentrations of dopamine- and serotonin-immunoreactive fibers in the lateral central nucleus and lateral dorsal bed nucleus lends further support to the idea of these areas as parallels in some respects to the striatum.
扩展杏仁核是一组结构，包括中央杏仁核和内侧杏仁核、终纹床核以及豆状核下无名质。这组结构被认为在多种精神疾病中起重要作用，其中许多疾病以某种方式与单胺及其转运体相关。然而，关于这些分子在灵长类动物扩展杏仁核中的分布情况，人们了解得并不多。因此，我们绘制了猕猴大脑中酪氨酸羟化酶、多巴胺β羟化酶、5-羟色胺、多巴胺转运体和5-羟色胺转运体免疫反应性纤维的分布图。酪氨酸羟化酶、5-羟色胺和5-羟色胺转运体免疫反应性纤维在中央核外侧部和终纹床核外侧背侧部分浓度最高。多巴胺β羟化酶免疫反应性纤维在终纹床核外侧腹侧浓度最高。多巴胺转运体免疫反应性纤维在终纹床核外侧近囊和外侧背侧囊亚核以及中央杏仁核外侧囊亚核中浓度最高，不过其含量比纹状体中的要低得多。这些结果表明这些递质发挥着重要作用，特别是在终纹床核外侧背侧和中央核外侧部分。扩展杏仁核中多巴胺转运体相对缺乏，这表明该递质更多地通过容积传递起作用，而5-羟色胺通常伴有相应数量的转运体，可能更像一种经典神经递质。此外，在中央核外侧和终纹床核外侧背侧发现大量多巴胺和5-羟色胺免疫反应性纤维，进一步支持了这些区域在某些方面与纹状体相似的观点。
