Masso J M, Conde J R, Villar A M, Martorell J
Department of Pharmacology, ELMU S.A., Madrid, Spain.
J Pharm Pharmacol. 1993 Nov;45(11):959-62. doi: 10.1111/j.2042-7158.1993.tb05635.x.
Fepradinol is an effective non-steroidal anti-inflammatory agent. The effect on rat paw oedema induced by various phlogistic agents was investigated. The inhibitory effect of fepradinol (25 mg kg-1, p.o.) on dextran-induced oedema was nearly equal to that of cyproheptadine (10 mg kg-1, p.o.). On oedema induced by platelet-activating factor only fepradinol (25 mg kg-1, p.o.) and phenidone (100 mg kg-1, p.o.) clearly inhibited the inflammatory process. Both the above induced oedemas are thought to be unrelated to prostaglandins in the rat system and therefore, the anti-inflammatory activity against them is not shared by selective cyclo-oxygenase inhibitors. Fepradinol (25 mg kg-1, p.o.) displayed an inhibitory effect on the early and late stage of kaolin- and nystatin-induced oedemas in contrast with indomethacin (10 mg kg-1, p.o.) and piroxicam (10 mg kg-1, p.o.) which only inhibited the late stage. The results obtained in this study confirm that fepradinol is a potent anti-inflammatory agent and indicate that its mechanism of action is different from that of other anti-inflammatory compounds.
非那丙醇是一种有效的非甾体抗炎药。研究了其对各种炎症介质诱导的大鼠足爪水肿的影响。非那丙醇（25毫克/千克，口服）对葡聚糖诱导的水肿的抑制作用几乎与赛庚啶（10毫克/千克，口服）相当。对于血小板活化因子诱导的水肿，只有非那丙醇（25毫克/千克，口服）和非那吡啶（100毫克/千克，口服）能明显抑制炎症过程。上述两种诱导的水肿被认为与大鼠体内的前列腺素无关，因此，选择性环氧化酶抑制剂对它们没有抗炎活性。与吲哚美辛（10毫克/千克，口服）和吡罗昔康（10毫克/千克，口服）仅抑制后期不同，非那丙醇（25毫克/千克，口服）对高岭土和制霉菌素诱导的水肿的早期和后期均有抑制作用。本研究结果证实非那丙醇是一种有效的抗炎药，并表明其作用机制与其他抗炎化合物不同。
