Henke R P, Krüger E, Ayhan N, Hübner D, Hammerer P
Institut für Pathologie, Universität Hamburg.
Verh Dtsch Ges Pathol. 1993;77:133-7.
Thirty-one routinely processed radical prostatectomy specimens were examined for the presence of numerical chromosomal aberrations by in situ hybridization with centromeric nucleic acid probes specific for chromosomes 7, 10, 17, X, and Y. In eight of the prostatectomy specimens, chromosome numbers consistent with a normal male karyotype were found. Three cases, in addition to diploid chromosome numbers, showed a focal doubling of hybridization signals, consistent with tetraploidy. The other 20 cases displayed more or less marked numerical chromosomal aberrations. In this group, the appearance of numerical chromosomal aberrations often showed considerable local heterogeneity and was significantly correlated with tumor stage, Gleason grades, and tumor volume. We conclude that in prostatic cancer the presence of numerical chromosomal aberrations is associated with advanced disease. Especially in low differentiated tumors local heterogeneity in chromosome numbers can be very marked.
通过使用针对7号、10号、17号染色体、X染色体和Y染色体的着丝粒核酸探针进行原位杂交，对31份常规处理的根治性前列腺切除术标本进行了检查，以确定是否存在染色体数目异常。在8份前列腺切除术标本中，发现染色体数目与正常男性核型一致。除了二倍体染色体数目外，有3例显示杂交信号局部加倍，与四倍体一致。其他20例显示出或多或少明显的染色体数目异常。在这一组中，染色体数目异常的表现往往显示出相当大的局部异质性，并且与肿瘤分期、 Gleason分级和肿瘤体积显著相关。我们得出结论，在前列腺癌中，染色体数目异常与疾病进展相关。特别是在低分化肿瘤中，染色体数目的局部异质性可能非常明显。
