甲状腺髓样癌中的甲状腺实性细胞巢。

Solid cell nests of the thyroid in medullary thyroid carcinoma.

作者信息

Ozaki O, Ito K, Fujisawa T, Kawano M, Iwabuchi H, Kitamura Y, Sugino K, Mimura T

机构信息

Surgical Branch, Ito Hospital, Tokyo, Japan.

出版信息

Histopathology. 1994 Jan;24(1):77-80. doi: 10.1111/j.1365-2559.1994.tb01274.x.

DOI:10.1111/j.1365-2559.1994.tb01274.x

PMID:7511561

Abstract

Solid cell nests of the thyroid gland were studied in 44 patients with medullary thyroid carcinoma. In 10 (22.7%) patients, solid cell nests were revealed in the vicinity of tumour foci (five cases) or in the contralateral thyroid lobe and isthmus (four cases); in one case the location was indeterminate. In all seven cases in which immunohistochemical studies were carried out, solid cell nests showed negative staining for thyroglobulin, calcitonin and chromogranin A, findings which were distinct from those in medullary thyroid carcinoma. It is therefore suggested that solid cell nests of the thyroid are not precursors of this tumour.

摘要

对44例甲状腺髓样癌患者的甲状腺实体细胞巢进行了研究。在10例（22.7%）患者中，在肿瘤病灶附近（5例）或对侧甲状腺叶及峡部（4例）发现了实体细胞巢；1例位置不确定。在进行免疫组织化学研究的所有7例中，实体细胞巢对甲状腺球蛋白、降钙素和嗜铬粒蛋白A呈阴性染色，这些结果与甲状腺髓样癌不同。因此，提示甲状腺实体细胞巢不是该肿瘤的前体。