Influences of alkylphenyl alpha-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A.

The influence of mannose, glucose, galactose and their corresponding methyl and phenyl glycopyranosides, as well as a series of alkylphenyl alpha-D-mannopyranosides, on histamine release from rat peritoneal mast cells induced by concanavalin A was examined. Among the compounds tested, the inhibitory effects of compounds bearing a 2,6-dimethyl substituent were stronger than the others. The results suggest that the binding ability of phenyl alpha-D-mannopyranoside may be markedly enhanced by the introduction of a 2,6-dimethyl substituent into the benzene nuclei of aglycones.