Lawrence J H, Tomaselli G F, Marban E
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Heart Dis Stroke. 1993 Jan-Feb;2(1):75-80.
Ion channels are ubiquitous membrane proteins in mammalian cells. Their critical physiological roles include control of the electrical potential across the membrane, facilitation of neuromuscular and neuronal transmission, signal transduction, and regulation of secretion and contractility. The alliance of techniques in biochemistry, electrophysiology, pharmacology, and molecular biology has provided insights into the three-dimensional structure of channel proteins and has allowed specific aspects of functional correlates to be better understood. Promises for the future include molecular genetic approaches to the treatment of disorders such as long QT syndrome and more rational design of drugs targeted to ion channels, including antiarrhythmic agents.
离子通道是哺乳动物细胞中普遍存在的膜蛋白。它们的关键生理作用包括控制跨膜电位、促进神经肌肉和神经元传递、信号转导以及调节分泌和收缩性。生物化学、电生理学、药理学和分子生物学技术的结合，为深入了解通道蛋白的三维结构提供了线索，并使人们能更好地理解功能相关性的具体方面。未来的前景包括采用分子遗传学方法治疗诸如长QT综合征等疾病，以及更合理地设计针对离子通道的药物，包括抗心律失常药物。
