调节激活正常T细胞表达和分泌的趋化因子增强了嗜酸性粒细胞产生的活性氧产物。

RANTES augments radical oxygen products from eosinophils.

作者信息

Chihara J, Hayashi N, Kakazu T, Yamamoto T, Kurachi D, Nakajima S

机构信息

Fourth Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Japan.

出版信息

Int Arch Allergy Immunol. 1994;104 Suppl 1(1):52-3. doi: 10.1159/000236752.

DOI:10.1159/000236752

PMID:7512397

Abstract

RANTES, which is released from thrombin-stimulated platelets, is a member of the 8-kD cytokine family that has been shown to possess chemotactic activity for eosinophils. Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils. RANTES treatment resulted in the enhancement of peak value and integrated value of productivity of eosinophil-mediated radical oxygen products determined by luminol-dependent chemiluminescence of EoL-3 cells stimulated with A23187. In addition, the radical oxygen products of EoL-1 or eosinophils showed similar results. Thus, we could conclude that platelets might play an important role in the pathogenesis of allergic inflammation through the involvement in the selective eosinophil infiltration and eosinophil activation by releasing RANTES.

摘要

RANTES由凝血酶刺激的血小板释放，是8-kD细胞因子家族的成员，已被证明对嗜酸性粒细胞具有趋化活性。因此，在本研究中，我们检测了RANTES对嗜酸性粒细胞产生的活性氧产物的影响。RANTES处理导致通过A23187刺激的EoL-3细胞的鲁米诺依赖性化学发光测定的嗜酸性粒细胞介导的活性氧产物产生的峰值和积分值增强。此外，EoL-1或嗜酸性粒细胞的活性氧产物也显示出类似结果。因此，我们可以得出结论，血小板可能通过释放RANTES参与选择性嗜酸性粒细胞浸润和嗜酸性粒细胞活化，从而在过敏性炎症的发病机制中发挥重要作用。