Department of Internal Medicine, Chungnam National University Medical School, Daejeon, Korea.
Molecules. 2010 Oct 4;15(10):6810-34. doi: 10.3390/molecules15106810.
Despite gaps in our knowledge of how phytochemicals interfere with cellular functions, several natural plant products are utilized to prevent or treat a wide range of diseases. Identification of an agent with therapeutic potential requires multiple steps involving in vitro studies, efficacy and toxicity studies in animal models, and then human clinical trials. This review provides a brief introduction on natural products that may help to treat and/or prevent bronchial asthma and describes our current understanding of their molecular mechanisms based on various in vitro, in vivo, and clinical studies. We focus on the anti-inflammatory and anti-vascular actions of the plant products and other roles beyond the anti-oxidative effects.
尽管我们对植物化学物质如何干扰细胞功能的了解存在差距，但仍有几种天然植物产品被用于预防和治疗多种疾病。具有治疗潜力的药物的鉴定需要经过多个步骤，包括体外研究、动物模型的疗效和毒性研究，然后是人体临床试验。本文简要介绍了可能有助于治疗和/或预防支气管哮喘的天然产物，并根据各种体外、体内和临床研究描述了我们目前对其分子机制的理解。我们专注于植物产物的抗炎和抗血管作用以及除抗氧化作用之外的其他作用。
