Sherriff F E, Henderson Z
Department of Physiology, University of Leeds, UK.
Brain Res. 1994 Feb 4;636(1):119-25. doi: 10.1016/0006-8993(94)90185-6.
Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tracing and choline acetyltransferase (ChAT) immunocytochemistry. The results confirm previous studies on the projections of the neurons of the pontomesencephalic tegmentum but also show that a group of ChAT-positive cells in the paragigantocellular nucleus in the ventral medulla are a source of widespread, albeit less substantial cholinergic projections to several areas of the brainstem.
已知脑桥中脑被盖的胆碱能神经元可支配脑干的许多部位，但这种支配的其他可能来源却很少被考虑。我们试图通过轴突束追踪和胆碱乙酰转移酶（ChAT）免疫细胞化学来研究脑干中的其他细胞是否负责这种胆碱能输入。结果证实了先前关于脑桥中脑被盖神经元投射的研究，但也表明延髓腹侧巨细胞旁核中的一组ChAT阳性细胞是向脑干几个区域广泛投射胆碱能纤维的来源，尽管其投射量较少。
