Gerecke D R, Wagman D W, Champliaud M F, Burgeson R E
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129.
J Biol Chem. 1994 Apr 15;269(15):11073-80.
We have isolated overlapping cDNA clones encoding the entire kalinin B1 chain. The predicted sequences are consistent with the models proposed for the structure of this chain as a truncated homologue of the B1 chain of laminin. The percent sequence homology with other laminin B1 chains is relatively low, suggesting that this chain is functionally different. The sequence of the VI domain of this chain is consistent with the possibility that it serves to bind specifically the kalinin A chain and subsequently covalently binds to it. In keeping with the accepted nomenclature for the laminin chains we name this novel polypeptide the laminin B1k chain.
我们已经分离出编码整个kalinin B1链的重叠cDNA克隆。预测的序列与所提出的该链结构模型一致，该模型认为它是层粘连蛋白B1链的截短同源物。与其他层粘连蛋白B1链的序列同源百分比相对较低，表明该链在功能上有所不同。该链VI结构域的序列与它可能特异性结合kalinin A链并随后与之共价结合的可能性一致。按照层粘连蛋白链的公认命名法，我们将这种新的多肽命名为层粘连蛋白B1k链。
