Mylonas Charalampos C, Lazaris Andreas C
1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Gastroenterol Res Pract. 2014;2014:580159. doi: 10.1155/2014/580159. Epub 2014 Dec 28.
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopathological correlations have many applications in cancer prognostication. Examples include the prediction of the medium patient survival and the screening for patients suitable for specific therapeutic approaches. Apart from traditional prognostic factors, such as tumor stage and grade, new markers may be useful in clinical practice. Possible markers may result from the study of basement membranes (BMs). BM seems to play a role in the pathogenesis of colorectal cancer, so BM alterations may have prognostic significance as well. The purpose of this review is to briefly describe BMs and their relationship with CRC, in the aspect of clinicopathological correlations.
结直肠癌（CRC）是男性中第三大最常被诊断出的癌症，在女性中则是第二大。2008年，估计有120万人被诊断出患有结直肠癌，608,700人死于该病。除了诊断和治疗，预后对于癌症患者来说也是一个重要问题。如今，临床病理相关性在癌症预后评估中有许多应用。例如，预测患者的平均生存期以及筛选适合特定治疗方法的患者。除了传统的预后因素，如肿瘤分期和分级外，新的标志物在临床实践中可能也有用处。可能的标志物可能来自于对基底膜（BMs）的研究。基底膜似乎在结直肠癌的发病机制中起作用，因此基底膜的改变可能也具有预后意义。本综述的目的是在临床病理相关性方面简要描述基底膜及其与结直肠癌的关系。
