乙胺嘧啶对培养的中国仓鼠（CHL）细胞染色体畸变的诱导作用。
Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells.
作者信息
Ono T, Norimatsu M, Yoshimura H
机构信息
National Veterinary Assay Laboratory, Tokyo, Japan.
出版信息
Mutat Res. 1994 Apr;323(4):197-201. doi: 10.1016/0165-7992(94)90033-7.
PMID:7512690
Abstract
Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine. Pyrimethamine without metabolic activation strongly induced structural chromosome aberrations in a dose-dependent manner. Aberrant metaphase cells occurred at a frequency of 80%, when cells were treated at 1.6 microgram/ml for 48 h.
摘要
在用乙胺嘧啶处理的培养中国仓鼠细胞中研究了染色体畸变的诱导情况。未经代谢活化的乙胺嘧啶以剂量依赖的方式强烈诱导染色体结构畸变。当细胞在1.6微克/毫升的浓度下处理48小时时，异常中期细胞的出现频率为80%。
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