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An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.

作者信息

Natarajan A T

机构信息

MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.

出版信息

Mutat Res. 1993 May;287(1):113-8. doi: 10.1016/0027-5107(93)90150-e.

DOI:10.1016/0027-5107(93)90150-e
PMID:7683377
Abstract

Ten known or suspected aneugens were analyzed in a variety of in vitro mammalian cell cultures using different endpoints which included: micronuclei, kinetochore-positive micronuclei in binucleated cells, changes in the number of chromosomes or aberrations of mitosis and division. Human lymphocytes, human diploid fibroblasts and Chinese hamster transformed cells were used as target cells. The relative merits of different in vitro test systems employed are briefly discussed here.

摘要

相似文献

1
An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
Mutat Res. 1993 May;287(1):113-8. doi: 10.1016/0027-5107(93)90150-e.
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A comparison of two in vitro mammalian cell cytogenetic assays for the detection of mitotic aneuploidy using 10 known or suspected aneugens.使用10种已知或疑似非整倍体诱导剂，对两种用于检测有丝分裂非整倍体的体外哺乳动物细胞细胞遗传学检测方法进行比较。
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The detection and assessment of the aneugenic potential of environmental chemicals: the European Community Aneuploidy Project.
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Mutat Res. 1993 Dec;303(4):163-9. doi: 10.1016/0165-7992(93)90018-q.

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