Synthesis and biological activity of NK1 tachykinin antagonists not containing D-residues.
作者信息
Poulos C, Antoniou M, Patacchini R, Maggi C A, Rovero P
机构信息
Department of Chemistry, University of Patras, Greece.
出版信息
Neuropeptides. 1994 Jan;26(1):55-7. doi: 10.1016/0143-4179(94)90093-0.
PMID:7512697
Abstract
A series of analogues of the previously reported NK1 tachykinin antagonist [Orn6, Glu(OBzl)11]-SP6-11-OBzl has been synthesized and tested in order to investigate the effects on antagonistic activity of modifications at the C-terminal residue. The biological activity in the guinea-pig ileum assay (NK1 receptor) indicates that the two aromatic rings introduced in the C-terminal part of the peptide are both essential for the expression of antagonistic activity.
摘要
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