Man'kovskiĭ N B, Karaban' I N, Kryzhanovskiĭ G N, Evseev V A, Magaeva S V, Vetrila L A, Trekova N A, Basharova L A, Golubev K M
Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(6):7-11.
Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more expressed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance formation is discussed.
在帕金森病患者的血清中发现了多巴胺抗体（DAb），这些患者为中老年群体，而非年轻人。中老年患者中DAb的发生率与主要症状之间存在相关性，老年患者中DAb与心绞痛型帕金森病之间也存在相关性。将帕金森病患者的DAb结合血清γ球蛋白注射到大鼠尾状核中，可诱发该脑区帕金森综合征的发病机制（病理性兴奋增强发生器-GPEE），并引发主要的帕金森病症状（运动迟缓、僵硬和震颤）。与年轻动物相比，这种效应在老年大鼠中更为明显。文中讨论了DAb在帕金森综合征发病机制和左旋多巴治疗耐受性形成中的作用。
