Takechi A, Uozumi T, Kawamoto K, Ito A, Kurisu K, Sudo K
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Anticancer Res. 1994 Jan-Feb;14(1A):157-62.
An angiogenic inhibitor, TNP-470, is an analogue of fumagillin. This study reports the effects of TNP-470 and bromocriptine on the normal pituitary glands and estrogen-induced rat pituitary tumors. TNP-470 inhibited the increase of normal pituitary weight and the tumorigenesis induced by estrogen. The decreased labelling index in the pituitary cells, showed that TNP-470 may suppress the activity of cell proliferation as the result of anti-angiogenesis. Combination treatment with TNP-470 and bromocriptine was much more effective than TNP alone. These results suggest that TNP-470 is a potentially beneficial drug for pituitary tumors.
血管生成抑制剂TNP - 470是烟曲霉素的类似物。本研究报告了TNP - 470和溴隐亭对正常垂体以及雌激素诱导的大鼠垂体肿瘤的影响。TNP - 470抑制了正常垂体重量的增加以及雌激素诱导的肿瘤发生。垂体细胞中标记指数的降低表明，TNP - 470可能由于抗血管生成作用而抑制细胞增殖活性。TNP - 470与溴隐亭联合治疗比单独使用TNP更有效。这些结果表明，TNP - 470对垂体肿瘤可能是一种有益的药物。
