Takechi A
Department of Neurosurgery, Hiroshima University School of Medicine.
Neurol Med Chir (Tokyo). 1994 Nov;34(11):729-33. doi: 10.2176/nmc.34.729.
TNP-470 (TNP), an analog of fumagillin, inhibits cell proliferation and tumorigenesis in estrogen-induced pituitary tumors in rats. This study found that treatment with TNP or TNP and bromocriptine suppressed vascular formation in these pituitary tumors more than bromocriptine alone. TNP had a greater suppressive effect on vascular formation in pituitary tumors than in normal pituitary gland. Laminin and basic fibroblast growth factor (FGF) were detected around new blood vessels in normal pituitary gland and pituitary tumor. TNP did not completely suppress laminin or basic FGF expression. The effect of TNP on pituitary tumor may involve inhibition of vascular formation by mechanisms mediated by other factors in addition to basic FGF. Treatment with bromocriptine and TNP acts indirectly and directly on vascular formation and may provide a useful chemotherapeutic modality for pituitary tumors.
TNP-470（TNP）是烟曲霉素的类似物，可抑制大鼠雌激素诱导的垂体肿瘤中的细胞增殖和肿瘤发生。本研究发现，用TNP或TNP与溴隐亭治疗比单独使用溴隐亭更能抑制这些垂体肿瘤中的血管形成。TNP对垂体肿瘤血管形成的抑制作用比对正常垂体更大。在正常垂体和垂体肿瘤的新血管周围检测到层粘连蛋白和碱性成纤维细胞生长因子（FGF）。TNP并未完全抑制层粘连蛋白或碱性FGF的表达。TNP对垂体肿瘤的作用可能除了碱性FGF之外，还涉及通过其他因子介导的机制抑制血管形成。溴隐亭和TNP治疗间接和直接作用于血管形成，可能为垂体肿瘤提供一种有用的化疗方式。
