携带v-Ha-ras癌基因小鼠的脾细胞产生肿瘤坏死因子的减少。
Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice.
作者信息
Chen G J, Colombo L L, Lopez M C, Watson R R
机构信息
Department of Family and Community Medicine, University of Arizona, Tucson 85624.
出版信息
Cancer Lett. 1993 Nov 1;74(3):147-50. doi: 10.1016/0304-3835(93)90236-3.
Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and gamma-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.
由小鼠乳腺肿瘤病毒启动子/增强子驱动的含有活化v-Ha-ras癌基因的小鼠，比没有该基因的基因相同的动物产生的肿瘤坏死因子（TNF）更少。将含有v-Ha-ras癌基因的近交系致癌小鼠和没有该基因的近交系FVB小鼠饲养6个月。分离脾细胞并在体外刺激以产生肿瘤坏死因子（TNF）和γ-干扰素（IFN）。与FBV小鼠的细胞相比，致癌小鼠细胞产生的TNF显著减少。IFN释放有下降趋势，但未观察到显著差异。这些观察结果表明癌基因可能在免疫系统中发挥作用。
Zotero 插件