酪氨酸羟化酶、P物质、神经肽Y和亮氨酸脑啡肽在发育中的人类视网膜无长突细胞中的免疫组织化学定位。

Immunohistochemical localization of tyrosine hydroxylase, substance P, neuropeptide-Y and leucine-enkephalin in developing human retinal amacrine cells.

作者信息

Jotwani G, Itoh K, Wadhwa S

机构信息

Department of Anatomy (2nd Division), Gifu University School of Medicine, Japan.

出版信息

Brain Res Dev Brain Res. 1994 Feb 18;77(2):285-9. doi: 10.1016/0165-3806(94)90204-6.

DOI:10.1016/0165-3806(94)90204-6

PMID:7513625

Abstract

Prenatal changes in the neurotransmitter/neuromodulator profiles of tyrosine hydroxylase (for dopamine), substance P, neuropeptide Y, and leucine-enkephalin were studied in developing human retinal amacrine cells by the use of immunohistochemical techniques. Tyrosine hydroxylase was localized between 10 and 12 weeks of gestation, substance P and neuropeptide Y appeared little later around 14 weeks, and leucine-enkephalin-like immunoreactivity was observed at 16 weeks.

摘要

通过免疫组织化学技术，研究了发育中的人类视网膜无长突细胞中酪氨酸羟化酶（用于多巴胺）、P物质、神经肽Y和亮氨酸脑啡肽的神经递质/神经调质谱的产前变化。酪氨酸羟化酶定位于妊娠10至12周之间，P物质和神经肽Y稍晚出现，约在14周左右，亮氨酸脑啡肽样免疫反应在16周时观察到。