曲磷胺对雄性小鼠特定位点和显性致死突变的诱导作用
Induction of specific-locus and dominant lethal mutations in male mice by trophosphamide.
作者信息
Ehling U H, Neuhäuser-Klaus A
机构信息
GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, Institut für Säugetiergenetik, Neuherberg, Oberschleissheim, Germany.
出版信息
Mutat Res. 1994 May 1;307(1):229-36. doi: 10.1016/0027-5107(94)90296-8.
PMID:7513801
Abstract
Trophosphamide induced dominant lethal and specific-locus mutations in spermatozoa and spermatids of mice. The induction pattern of specific-locus and dominant lethal mutations shows two maxima in the mating intervals 1-4 and 9-16 days post treatment. The nature of induced mutations is suggested to be intergenic.
摘要
曲磷酰胺可诱导小鼠精子和精细胞发生显性致死突变和特定基因座突变。特定基因座突变和显性致死突变的诱导模式在处理后的交配间隔1 - 4天和9 - 16天出现两个峰值。推测诱导突变的性质为基因间的。
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