Rooks M D, Rodriguez J, Blechner M, Zusmanis K, Hutton W
Section of Hand and Microvascular Surgery, Emory University School of Medicine, Atlanta, GA.
Microsurgery. 1994;15(2):123-9. doi: 10.1002/micr.1920150207.
Using a rat femoral artery crush-avulsion model previously described by the authors (Rooks et al.: Microsurgery 14: 130-134, 1993), we analyzed the relative efficacy of intraarterially delivered anticoagulants against similar systemically administered intravenous anticoagulants with double blinded experimentation. The model uses a standardized crush of approximately 0.3 J and a standardized avulsion. This is followed by vascular stasis for 90 seconds after vessel repair. All rats were limited to 175 to 225 gm in weight to control vessel size. Urokinase, heparin sodium, and dextran (40,000 Dalton) were evaluated in this study. A statistically significant (p-value = 0.02) increase in urokinase efficacy was found with intraarterial delivery. (Patency rate increased from 40% to 100%). No advantage to intraarterial delivery was evident with either dextran or heparin. There was a dose related improvement in patency with heparin that was unaffected by delivery route. (Patency increased from 30% to 80% with a statistical p-value of 0.018.)
利用作者先前描述的大鼠股动脉挤压-撕脱模型（Rooks等人：《显微外科手术》14: 130 - 134, 1993），我们通过双盲实验分析了动脉内给予抗凝剂相对于全身静脉给予类似抗凝剂的相对疗效。该模型采用约0.3焦耳的标准化挤压和标准化撕脱。血管修复后接着是90秒的血管淤滞。所有大鼠体重限制在175至225克以控制血管大小。本研究评估了尿激酶、肝素钠和右旋糖酐（40,000道尔顿）。发现动脉内给药时尿激酶疗效有统计学显著提高（p值 = 0.02）。（通畅率从40%提高到100%）。右旋糖酐或肝素动脉内给药均无明显优势。肝素的通畅率有剂量相关改善，且不受给药途径影响。（通畅率从30%提高到80%，统计学p值为0.018）
