Rooks M D, Rodriquez J, McNaughton M, Turnidge K, Zusmanis K, Hutton W
Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA.
Microsurgery. 1993;14(2):130-4. doi: 10.1002/micr.1920140209.
A model for studying arterial crush-avulsion injuries in the rat is described. The model uses a standardized crush of approximately 0.3 joules and a standardized avulsion. The crush is accomplished by gravity acceleration of a 400 g weight over a distance of 7.5 cm. The weight impacts an anvil over the artery distributing the force of the impact over a 10 mm length of the vessel. The avulsion is accomplished by a hemostat attached to a second, 120g weight. Vascular stasis for 90 sec after vessel repair in a 175-225 g rat will consistently result in an 80% anastomotic failure. The model allows evaluation of anticoagulant effects singly or in combination. Agents may be given either systemically by intravenous route or locally by intraarterial route.
本文描述了一种用于研究大鼠动脉挤压-撕脱伤的模型。该模型采用约0.3焦耳的标准化挤压和标准化撕脱。挤压通过400克重物在7.5厘米距离上的重力加速来完成。重物撞击动脉上方的砧座，将撞击力分布在10毫米长的血管上。撕脱通过连接到第二个120克重物的止血钳来完成。在175-225克的大鼠中，血管修复后90秒的血管淤滞将持续导致80%的吻合失败。该模型允许单独或联合评估抗凝效果。药物可通过静脉途径全身给药或通过动脉途径局部给药。
