Akenzua G, Akinyanju O, Kulozik A, Whitehead S, Morris J, Serjeant B E, Serjeant G
Dept of Child Health, University of Benin Teaching Hospital, Nigeria.
Afr J Med Med Sci. 1994 Jun;23(2):101-7.
The clinical and haematological features of 77 patients of Bini and 107 patients of Yoruba origin with homozygous sickle cell (SS) disease have been compared. The Bini population were generally younger and had a slightly lower incidence of alpha thalassaemia but even after correction for age and alpha thalassaemia status, this group had significantly lower HbA2 and higher HbF and MCV values. Clinically the Bini group had significantly less dactylitis and more acute chest syndrome. The decreased frequency of dactylitis is consistent with the higher HbF level in the Bini population and the mechanism of the other effects are discussed.
对77名来自比尼族和107名来自约鲁巴族的纯合子镰状细胞（SS）病患者的临床和血液学特征进行了比较。比尼族人群总体上更年轻，α地中海贫血的发病率略低，但即使在对年龄和α地中海贫血状态进行校正后，该组的HbA2水平仍显著较低，HbF和MCV值较高。临床上，比尼族组的指（趾）炎明显较少，急性胸部综合征较多。指（趾）炎频率降低与比尼族人群中较高的HbF水平一致，并对其他影响的机制进行了讨论。
