大鼠蛛网膜下腔出血后脑干下部单胺能神经元功能的变化。
Changes in monoaminergic neuronal function in the lower brain stem following subarachnoid hemorrhage induced in rats.
作者信息
Hirata K, Kawano T, Mori K
机构信息
Department of Neurosurgery, Nagasaki University School of Medicine, Japan.
出版信息
Cell Mol Neurobiol. 1993 Dec;13(6):639-48. doi: 10.1007/BF00711563.
Abstract
- We investigated the function of monoaminergic neurons in the lower brain stem following subarachnoid hemorrhage (SAH) induced in rats, by measuring monoamine metabolites, using in vivo microdialysis techniques. 2. A dialysis probe was implanted in the nucleus tractus solitarius (NTS) and the perfusates were assayed by high-performance liquid chromatography (HPLC) with electrochemical detection (ECD). 3. The main monoamine metabolites measured in the NTS extracellular space were 3,4-dihydroxyphenyl acetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). 4. Monoamine metabolites in the rat NTS were nonspecifically increased, at least in the acute phase after cisternal injection of blood or saline. 5. The disappearance rates of the 5-HIAA decline and the early phase of DOPAC decline after pargyline administration (75 mg/kg, i.p.) were most rapid at 2 days after the induction of SAH, then recovered gradually. 6. These results suggest that functions of noradrenergic and serotonergic neurons in the NTS may be disturbed predominantly in the case of induced vasospasm in rats.
摘要
- 我们通过使用体内微透析技术测量单胺代谢产物，研究了大鼠蛛网膜下腔出血（SAH）后脑干下部单胺能神经元的功能。2. 将透析探针植入孤束核（NTS），并通过高效液相色谱（HPLC）和电化学检测（ECD）对灌注液进行分析。3. 在NTS细胞外空间测量的主要单胺代谢产物是3,4-二羟基苯乙酸（DOPAC）、高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）。4. 大鼠NTS中的单胺代谢产物非特异性增加，至少在脑池内注射血液或盐水后的急性期如此。5. 给予帕吉林（75mg/kg，腹腔注射）后，5-HIAA的消失率下降，DOPAC下降的早期阶段在SAH诱导后2天最快，然后逐渐恢复。6. 这些结果表明，在大鼠诱导血管痉挛的情况下，NTS中去甲肾上腺素能和5-羟色胺能神经元的功能可能主要受到干扰。
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本文引用的文献
1
Cerebrovascular reactivity to noradrenaline and serotonin following experimental subarachnoid hemorrhage.实验性蛛网膜下腔出血后脑血管对去甲肾上腺素和5-羟色胺的反应性
J Neurosurg. 1980 Oct;53(4):480-5. doi: 10.3171/jns.1980.53.4.0480.
2
Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries.实验性蛛网膜下腔出血对脑动脉肾上腺素能神经支配的影响。
J Neurosurg. 1980 Oct;53(4):477-9. doi: 10.3171/jns.1980.53.4.0477.
3
Plasma catecholamine concentrations associated with cerebral vasospasm.
J Neurol Sci. 1980 Mar;45(2-3):261-71. doi: 10.1016/0022-510x(80)90170-7.
4
Reduced noradrenaline uptake and retention in cerebrovascular nerves associated with angiographically visible vasoconstriction following experimental subarachnoid hemorrhage in rabbits.实验性蛛网膜下腔出血后，兔脑血管神经中去甲肾上腺素摄取和潴留减少，与血管造影可见的血管收缩有关。
Brain Res Bull. 1982 Jul-Dec;9(1-6):799-805. doi: 10.1016/0361-9230(82)90187-3.
5
Norepinephrine in cerebrospinal fluid of patients with cerebral vasospasm.脑血管痉挛患者脑脊液中的去甲肾上腺素
J Neurosurg. 1982 Mar;56(3):344-9. doi: 10.3171/jns.1982.56.3.0344.
6
Anatomical organization of central respiratory neurons.中枢呼吸神经元的解剖结构
Annu Rev Physiol. 1981;43:105-20. doi: 10.1146/annurev.ph.43.030181.000541.
7
The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat.大鼠中从脑干到室旁核和视上核的去甲肾上腺素能通路的组织架构。
Brain Res. 1982 Nov;257(3):275-325. doi: 10.1016/0165-0173(82)90010-8.
8
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J Neurosci. 1984 Apr;4(4):966-77. doi: 10.1523/JNEUROSCI.04-04-00966.1984.
9
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