Tzourio N, Heim A, Zilbovicius M, Gerard C, Mazoyer B M
Groupe d'Imagerie Neurofonctionnelle, DRIPP CEA, Orsay, France.
Pediatr Neurol. 1994 Feb;10(1):20-6. doi: 10.1016/0887-8994(94)90062-0.
This study used xenon 133 inhalation and single-photon computed tomography to measure regional cerebral blood flow during a quiet resting condition, a simple auditory task, and an auditory phonemic discrimination task in 3 age-matched groups of children suffering from developmental language disabilities: expressive dysphasia, expressive-receptive dysphasia, and attention-deficit hyperactivity disorder. An absence of left hemisphere activation was observed in the expressive-receptive group during the phonemic discrimination task as compared to both expressive and attention-deficit hyperactivity disorder children, together with an absence of left inferior parietal region activation in dysphasics as compared to hyperactive children. These results favor the hypothesis of an abnormal lateralization for language in dysphasic children and point toward possible different pathologic localizations in the different clinical subtypes of dysphasia.
本研究采用氙133吸入法和单光子计算机断层扫描技术，在安静休息状态、简单听觉任务以及听觉音素辨别任务期间，对3组年龄匹配的患有发育性语言障碍的儿童进行局部脑血流量测量，这3组儿童分别为表达性言语障碍、表达-感受性言语障碍和注意力缺陷多动障碍。与表达性言语障碍儿童和注意力缺陷多动障碍儿童相比，在音素辨别任务期间，表达-感受性言语障碍组未观察到左半球激活；与多动儿童相比，言语障碍儿童的左下顶叶区域未激活。这些结果支持言语障碍儿童语言侧化异常的假说，并指出言语障碍不同临床亚型可能存在不同的病理定位。
