Chicz R M, Urban R G
Protein Microchemistry Facility, Harvard University, Cambridge, MA 02138.
Immunol Today. 1994 Apr;15(4):155-60. doi: 10.1016/0167-5699(94)90311-5.
T cells recognize antigenic peptides presented on the cell surface by major histocompatibility complex (MHC) molecules. Here, Roman Chicz and Robert Urban describe the features of peptides bound to MHC molecules and the mechanism by which these surface proteins bind diverse peptide ligands with high affinity. In addition, they discuss the application of new technologies to the identification of MHC-associated peptides.
T细胞识别由主要组织相容性复合体（MHC）分子呈递在细胞表面的抗原肽。在此，罗曼·奇茨和罗伯特·厄本描述了与MHC分子结合的肽的特征，以及这些表面蛋白以高亲和力结合多种肽配体的机制。此外，他们还讨论了新技术在鉴定MHC相关肽方面的应用。
