Yewdell J W, Bennink J R
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Semin Hematol. 1993 Oct;30(4 Suppl 4):26-32; discussion 33-4.
T lymphocytes play a critical role in host immunity, autoimmunity, and tissue rejection. There has been tremendous progress in understanding the molecular basis of T-cell recognition of foreign and self antigens. It is now well established that the major histocompatibility complex (MHC)-restricted nature of T-cell recognition is due to the interaction of the T-cell antigen receptor with MHC class I or II molecules bearing short peptides derived from antigenic proteins. In this report, we review recent progress in understanding antigen processing, ie, the mechanism by which antigenic peptides are generated in antigen-presenting cells and delivered to the appropriate MHC molecule in the appropriate intracellular compartment.
T淋巴细胞在宿主免疫、自身免疫和组织排斥中发挥着关键作用。在理解T细胞识别外来和自身抗原的分子基础方面已经取得了巨大进展。现在已经明确，T细胞识别的主要组织相容性复合体（MHC）限制性质是由于T细胞抗原受体与携带源自抗原性蛋白质的短肽的MHC I类或II类分子相互作用所致。在本报告中，我们综述了在理解抗原加工方面的最新进展，即抗原呈递细胞中抗原性肽的产生机制以及在适当的细胞内区室中递送至适当的MHC分子的机制。
