Martelletti P, Stirparo G, Rinaldi C, Fusco B M
Headache Center, University La Sapienza, Rome, Italy.
Cephalalgia. 1994 Feb;14(1):11-5; discussion 4. doi: 10.1046/j.1468-2982.1994.1401011.x.
We propose a model for assessing the function of 5HT receptors in migraine by evaluating their expression on monocytes by means of double-labeling fluorocytometry (CD14-positive cells FITC-labeled). This model demonstrates that during headache induced in migraine without aura sufferers given isosorbide dinitrate followed by sumatriptan treatment 5HT expression on monocytes progressively increases. This increase may be due to the activation of 5HT turnover and to the increased availability of 5HT displaced by sumatriptan from cerebrovascular receptors during head pain.
我们提出了一种通过双标记荧光细胞术（FITC标记的CD14阳性细胞）评估单核细胞上5-羟色胺（5HT）受体表达，从而评估偏头痛中5HT受体功能的模型。该模型表明，在无先兆偏头痛患者中，给予硝酸异山梨酯后诱发头痛，随后进行舒马曲坦治疗，单核细胞上的5HT表达会逐渐增加。这种增加可能是由于5HT代谢的激活，以及在头痛期间舒马曲坦从脑血管受体置换出的5HT可用性增加所致。
