Martelletti P, Stirparo G, Rinaldi C, Giacovazzo M
Department of Clinical Medicine, Headache Centre, University La Sapienza, Rome, Italy.
Int J Clin Pharmacol Res. 1994;14(5-6):165-75.
The double-label flow cytometric analysis of peripheral serotonergic pathways of migraine and cluster headache on a monocyte model has been used to evaluate the activity of drugs with a selective activity on central vascular 5-HT1D receptors, such as sumatriptan, ergotamine and ondansetron. The results indicated that sumatriptan and ergotamine progressively increase the peripheral expression of 5-HT (5-hydroxytryptamine, serotonin). The increase obtained in migraine after ergotamine is more evident than that obtained in cases of cluster headache. Ondansetron produced a moderate increase in serotonergic expression only in cluster headache. The events that occur at intracranic neural and vascular level may cause the described changes of 5-HT expression on the monocyte model as an indirect, reflective, peripheral registration of central serotonergic variations during headache attack as well as during the drug-sustained recovery phase.
在单核细胞模型上对偏头痛和丛集性头痛的外周血清素能通路进行双标记流式细胞术分析，已被用于评估对中枢血管5-HT1D受体具有选择性活性的药物的活性，如舒马曲坦、麦角胺和昂丹司琼。结果表明，舒马曲坦和麦角胺可逐渐增加5-HT（5-羟色胺，血清素）的外周表达。麦角胺治疗偏头痛后5-HT表达的增加比丛集性头痛病例更为明显。昂丹司琼仅在丛集性头痛中使血清素能表达适度增加。颅内神经和血管水平发生的事件可能会导致单核细胞模型上5-HT表达的上述变化，作为头痛发作期间以及药物持续恢复阶段中枢血清素能变化的间接、反射性外周记录。
