Joypaul B V, Kennedy N, Hanson J, Holley M, Browning M, Newman E L, Cuschieri A
Department of Surgery, University of Dundee, Ninewells Hospital and Medical School, UK.
J R Coll Surg Edinb. 1994 Feb;39(1):39-43.
Immunoscintigraphy with CYT-103, an 111indium-labelled immunoconjugate of B72.3, was evaluated in 10 patients before surgery for suspected or biopsy-proven primary colorectal cancer. The imaging results were compared with computed tomography (CT) findings at surgery, histopathology and immunohistochemistry. There were no adverse reactions following the administration of 1.0 mg 111In-CYT-103. Surgical and pathological findings identified 15 sites of disease (10 primary and five metastatic) and all but one lesion (severe dysplasia) were malignant. CT detected nine of 14 sites of malignancy compared to 12 as identified by immunoscintigraphy. It failed to detect two primary lesions and one case of peritoneal metastasis, all of which were imaged by CYT-103. Both imaging modalities failed to detect two of three cases with lymph node metastases and the dysplastic lesion (true negatives). The results indicate that 111In-CYT-103 imaging exhibits high sensitivity and specificity in the detection of primary and secondary lesions in patients with colorectal cancer.
对10例疑似或经活检证实为原发性结直肠癌的患者，在手术前使用CYT - 103（一种铟 - 111标记的B72.3免疫偶联物）进行免疫闪烁显像评估。将成像结果与手术时的计算机断层扫描（CT）结果、组织病理学和免疫组织化学结果进行比较。注射1.0毫克铟 - 111 - CYT - 103后未出现不良反应。手术和病理检查发现15个病变部位（10个原发性和5个转移性），除1个病变（重度发育异常）外均为恶性。CT检测出14个恶性病变部位中的9个，而免疫闪烁显像检测出12个。CT未能检测出2个原发性病变和1例腹膜转移，而这些均被CYT - 103成像检测到。两种成像方式均未能检测出3例淋巴结转移病例中的2例以及发育异常病变（真阴性）。结果表明，铟 - 111 - CYT - 103成像在检测结直肠癌患者的原发性和继发性病变方面具有高灵敏度和特异性。
