Mörschel M, Bockisch A, Junginger T
Klinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz.
Chirurg. 1995 May;66(5):503-6.
From April 1, 1992 to December 31, 1993 we investigated 30 patients with suspected primary colorectal carcinoma or questionable tumor relapse by immunoscintigraphy prospective with the monoclonal antibody MAb B72.3 in order to detect the tumor and especially regional lymph node metastases. All the patients underwent surgical treatment. The diagnosis was based on surgery and biopsy. The diagnostic sensitivity of immunoscintigraphy in detecting the tumor was 76%, the specificity 94% (predictive value positive [PVP] 95%) and 43%, respectively 85% in detecting lymph node metastases (PVP 60%). The diagnostic sensitivity in detecting rectosigmoid tumors was 79 and 60% in detecting lymph node metastases of rectosigmoid carcinoma (PVP 60%). The specificity was 90%. It could be shown, that the detection of metastases in singularly lymph nodes smaller than 1 cm was not possible and often a final decision could not be done. We conclude, that the benefit of this method in detection of lymph node metastases compared to basic diagnostic, expenses and costs is doubtfully.
1992年4月1日至1993年12月31日，我们采用单克隆抗体MAb B72.3对30例疑似原发性结直肠癌或可疑肿瘤复发的患者进行了前瞻性免疫闪烁显像检查，以检测肿瘤，尤其是区域淋巴结转移情况。所有患者均接受了手术治疗。诊断基于手术和活检。免疫闪烁显像检测肿瘤的诊断敏感性为76%，特异性为94%（阳性预测值[PVP]为95%）；检测淋巴结转移的敏感性分别为43%和85%（PVP为60%）。检测直肠乙状结肠肿瘤的诊断敏感性为79%，检测直肠乙状结肠癌淋巴结转移的敏感性为60%（PVP为60%）。特异性为90%。结果表明，无法检测到单个直径小于1 cm的淋巴结中的转移灶，且往往无法做出最终诊断。我们得出结论，与基本诊断方法相比，该方法在检测淋巴结转移方面的益处、费用和成本存疑。
